Chronic disease and its alteration of serum mucoid fraction patterns.

The disc electrophoresis advanced by Ornstein and Davis1 is the most useful method among various zone electrophoreses for separating proteins in sera. Using this method, the present author has observed and published in the pre vious paper2 the change of protein fraction patterns of human serum in several diseases and other biological materials. A marked increase of amount of serum mucoid in inflammatory diseases and malignant tumors has already been noticed by many investigators. Recently Price et al.3 have emphasized the importance of serum mucoid fraction patterns divided into five types from the viewpoint of diagnosing such chronic diseases as tuberculosis, schizophrenia and malignant tumor. The present paper presents a relationship between serum mucoid fraction patterns and blood sedimentation rates (BSR) to obtain information for dif erential diagnosis of pulmonary tuberculosis, gastric cancer and multiple mye loam. Goa's method4 was used here to simplify the usual tedious prosess as to isolation of serum mucoid.